Chicken Egg Yolk Immunoglobulin (IgY) is an antibody present in high concentrations in the egg yolk of chicken eggs. It is also produced by other birds and reptiles (Xu, et al., 2011). Egg laying hens usually deposit the large quantities of serum IgY in the egg yolk before laying eggs. These antibodies protect the developing chicken embryo from the potential disease agents (Xu, et al., 2011).
When hens are immunized against certain pathogens, they produce large quantities of IgY that are responsive to the specific antigen (pathogen) that causes a particular disease that they are immunized against (Xu, et al., 2011). Medical researchers have carried out research on IgY and its potential uses in the prevention and …show more content…
Numerous immunized hens are capable of laying eggs on a daily basis that contain large quantities of IgY (Xu, et al., …show more content…
IgY is also inactivated at a pH of less than 3.0 (Xu, et al., 2011). IgY has a shorter half-life of 1.85 days, in newborn pigs than IgG that has a half-life of 12-14 days, in newborn pigs (Xu, et al., 2011). Additionally, IgY is more effective against the Gram-negative bacteria than with the Gram-positive bacteria. This limit the type diseases that IgY can treat (Xu, et al., 2011). Since IgY does not directly kill bacteria, it is more effective when used for prophylaxis than when used for the treatment of diseases (Xu, et al., 2011). Since IgY does not bind with Protein A or Protein G, its isolation from egg yolk is more difficult than the isolation of IgG from blood serum (Xu, et al., 2011). This makes IgY production very expensive because it needs complicated technologies to obtain it in pure form (Xu, et al.,