Cetirizine

This report discusses the experiment conducted to test the degradation of cetirizine potency in Goodsense All Day Allergy pills after being stored under extreme conditions. Cetirizine is a H1-receptor antagonist often used in medications for the treatment of allergic diseases. Numerous studies show that 10 mg, the suggested daily dosage, is highly potent and prevents the mild side effects from an allergic reaction [1]. Through research, it has been proven that cetirizine has many favorable pharmacological properties. One property is cetirizine’s ability to hit target receptors and not be toxic to other organs it comes in contact with. Furthermore, it is absorbed extensively and rapidly through the gut which leads to a faster onset of the actions of the drugs.Cetirizine has a low hepatic metabolism, thus it has also has a low potential for drug-drug interactions. Cetirizine is also advantageous because of its relatively high and favorable affinity and selectivity for H1-receptors, which causes it to have a more potent, faster onset and a longer duration of effectiveness [2].The recommended conditions that medications are to be stored, so that it remains potent, are printed on the box or label as it is required by federal FDA regulations. The proposed storage conditions given for our drug, Goodsense All Day …show more content…
The environmental chamber was set to a constant temperature and relative humidity of 70.0℃/75.0%RH, to represent the extreme conditions applied on the drugs. The caps remained off the vials so that humidity had an opportunity to fully reach the pill. Before placing the pills in the vials, they were also cut in half to increase contact between the pill and the humidity. Starting with a control, the pills were pulled every other week and capped in order to measure the degradation of the course of eight