Cell Aging Research Paper

Cell aging and its mechanism has been a hot research topic. A large number of research results indicated that the aging degree of animals is inversely related to the mitochondrial function. The function of mitochondria is becoming weaker and weaker with the increase of aging degree [1-6]. Mitochondria generate ATP through the process of oxidative phosphorylation, simultaneously reactive oxygen species. Early researchs has proven that oxidative damage caused by reactive oxygen species is one of the reasons of the cell aging [7]. The intracellular reactive oxygen species generated by mitochondrial respiration, therefore, mitochondrial protein and mitochondrial DNA were more accessible active oxygen and active oxygen damage [8-15]. Mitochondrial DNA damage leads to the damage of mitochondrial function, which leads to cell dysfunction, and leads to cell aging eventually. In theory, if the damaged mitochondria can be repaired the cell function will be restored, thereby producing anti-aging effects. …show more content…
We found that airway ciliary beat frequency in aged C57BL/6 mice was lower than that of the young mice significantly ,and the transplantation of mitochondria derived from younger or older airway epithelial cells can significantly improve the airway cilia beat frequency in aged C57BL/6 mice.We also identified the mechanisms underlying the effects of transplanted mitochondria, which was associated with the mitochondrial dysfunction caused by increased mitochondrial DNA mutation rate during the aging process. Our study points to the determinant role of mitochondria in aging