There are so many different types of autoimmune diseases in society today, but on of the most common diseases among us humans today is Celiac Disease. Celiac Disease is a serious autoimmune disorder/ disease where if a person ingest gluten it can lead to the damaging of their small intestine. It is estimated to affect 1 in every 133 Americans or even 1 in every 100 people worldwide. That is about 1% of the population. Also, two and one-half million Americans are undiagnosed and are at risk for long-term health complications. Celiac disease can affect men and women of all ages. If your parents or even siblings have celiac disease then there is a 10% chance that you have the disease. This disease is more likely to be in people with a genetic disorder such as: down syndrome, turner syndrome, and ect. A way you can tell if you or someone has Celiac disease is by the following symptoms: weight loss, fatigue, vomiting, bloating, weakness, diarrhea, and gas.
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The damage to the small intestine also makes it hard for your body to absorb vitamins, minerals, and other nutrients. This is because the villi is affected. The villi is affected due to the immune system mistakes a part of the body as an invader and the infection- fighting white blood cells begin attacking the lining of your small intestine. Due to an epithelial cell stress caused by gluten protein entering the small intestine, which then leads to increased expression of the IL-15, HLA-E, AND MIC antigens/cytokines. This increased expression causes and increase in the susceptibility of the CTL attack. Thus, causing epithelial cell killing, which is also known as the damaging of the villious atrophy. Also, the CD4+T tries to help the killing of the CTL so that the villi doesnt get damaged but most time it is not successful at killing the
The damage to the small intestine also makes it hard for your body to absorb vitamins, minerals, and other nutrients. This is because the villi is affected. The villi is affected due to the immune system mistakes a part of the body as an invader and the infection- fighting white blood cells begin attacking the lining of your small intestine. Due to an epithelial cell stress caused by gluten protein entering the small intestine, which then leads to increased expression of the IL-15, HLA-E, AND MIC antigens/cytokines. This increased expression causes and increase in the susceptibility of the CTL attack. Thus, causing epithelial cell killing, which is also known as the damaging of the villious atrophy. Also, the CD4+T tries to help the killing of the CTL so that the villi doesnt get damaged but most time it is not successful at killing the