Celiac disease and type 1 diabetes are autoimmune disorders within the human body. An autoimmune disorder is a condition where the antibodies of the immune system attack the healthy cells and tissues. Since they’re both autoimmune disorders, the possibility of them being related genetically increases due to same genes to trigger the immune response. Scientist are investigating the possibility of these two disorders having a genetic similarity, causing individuals who have celiac to be more susceptible to type 1 diabetes and vice versa. Scientist and researchers are using the technique of genotyping to investigate the genetic variations of celiac and type 1 diabetes to determine if genetically they’re related or not. Celiac disease, also
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In this disorder, the immune system response to attack the small intestine when the body ingests certain proteins, for example gluten (Routhier 2005). The attack on the small intestine wall damages the wall and the villi which are the little hair like structures inside your intestines to absorb nutrients (Routhier 2005). The damage done to the intestine prevents proper absorption of nutrients leading the body to be malnourished (Routhier 2005). Celiac is a difficult disease to diagnose due to it affecting individuals in different ways (Celiac Disease Symptoms). Common symptoms include abdominal pain, vomiting, constipation, fatigue, bone and joint pain, and depression (Celiac Disease Symptoms). Individuals may experience symptoms for years before being diagnosed, as one case of this phenomenon is with Regina Erskine who went 6 years before she was diagnosed with celiac at 38 years old (Routhier 2005). The genes involved with celiac carry at least one copy of HLA haplotype DR3-DQ2.5 or DR4-DQ8, being …show more content…
Insulin is the hormone that allows people to obtain energy from the food they eat (Type 1 Diabetes Facts). Individuals who have insulin dependent diabetes need balance the amount of insulin they need to obtain based on what they eat and the amount of exercise they do (Type 1 Diabetes Facts). Diagnosis can happen at any age with symptoms such as extreme thirst, frequent urination, sudden weight loss, ext. (Warning signs of type 1 diabetes). Doctors give patients who believe they may have diabetes an oral glucose tolerance test that provides a map to help find any abnormalities (Warning signs of type 1 diabetes). The genes involved with type 1 diabetes are located on two chromosome regions: one is the MHCHLA on chromosome 6p21 also known as IDDM1, and on the insulin gene region on chromosome 11p5 known as IDDM2 (Davies et al. 1994) (Dean, McEntyre 2004). These genes that are associated with type 1 diabetes are genetically heterogenous, but different genes are more susceptible by environmental and gene factors to trigger (Davies et al. 1994). The immune system produces proteins for itself, using the genes HLA-DQA1, HLA-DQB1, and HLA-DRB1 (Type 1 diabetes). The term HLA stand for human leukocyte antigen complex, which is an encoding of certain proteins for the immune
In this disorder, the immune system response to attack the small intestine when the body ingests certain proteins, for example gluten (Routhier 2005). The attack on the small intestine wall damages the wall and the villi which are the little hair like structures inside your intestines to absorb nutrients (Routhier 2005). The damage done to the intestine prevents proper absorption of nutrients leading the body to be malnourished (Routhier 2005). Celiac is a difficult disease to diagnose due to it affecting individuals in different ways (Celiac Disease Symptoms). Common symptoms include abdominal pain, vomiting, constipation, fatigue, bone and joint pain, and depression (Celiac Disease Symptoms). Individuals may experience symptoms for years before being diagnosed, as one case of this phenomenon is with Regina Erskine who went 6 years before she was diagnosed with celiac at 38 years old (Routhier 2005). The genes involved with celiac carry at least one copy of HLA haplotype DR3-DQ2.5 or DR4-DQ8, being …show more content…
Insulin is the hormone that allows people to obtain energy from the food they eat (Type 1 Diabetes Facts). Individuals who have insulin dependent diabetes need balance the amount of insulin they need to obtain based on what they eat and the amount of exercise they do (Type 1 Diabetes Facts). Diagnosis can happen at any age with symptoms such as extreme thirst, frequent urination, sudden weight loss, ext. (Warning signs of type 1 diabetes). Doctors give patients who believe they may have diabetes an oral glucose tolerance test that provides a map to help find any abnormalities (Warning signs of type 1 diabetes). The genes involved with type 1 diabetes are located on two chromosome regions: one is the MHCHLA on chromosome 6p21 also known as IDDM1, and on the insulin gene region on chromosome 11p5 known as IDDM2 (Davies et al. 1994) (Dean, McEntyre 2004). These genes that are associated with type 1 diabetes are genetically heterogenous, but different genes are more susceptible by environmental and gene factors to trigger (Davies et al. 1994). The immune system produces proteins for itself, using the genes HLA-DQA1, HLA-DQB1, and HLA-DRB1 (Type 1 diabetes). The term HLA stand for human leukocyte antigen complex, which is an encoding of certain proteins for the immune