Cd4 + T Cells : Adaptive Immune Response Essay examples

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CD4+ T lymphocytes, or cells, are white blood cells that are involved in immune protection. These cells assist B cells in creating antibodies, allow macrophages to establish heightened antimicrobial activity, recruit neutrophils, eosinophils, and basophils towards inflammation and infection. CD4+ T cells also produce a group of cytokines, which respectively, trigger an abundance of immune responses.
T cell differentiation Originally, Mosmann et al., 1986 reported that CD4 T cells can be subdivided into those that produce interferon gamma (IFN-ϒ) and those that produce interleukin 4 (IL-4). Currently, CD4 T cells are recognized as a cell population with a variety of functions. Two subsets of CD4+ T cells that are recognized individually are natural regulatory T (nTreg) cells and natural killer T (NKT) cells. These distinct subsets have straightforward differentiation patterns, compared to the differentiation of helper T cells. Regulatory T cells are part of the adaptive immune response and are derived from the thymus. Treg cells are known as CD4+CD25+ T cells. They maintain immune cell homeostasis during inflammation and disease. NKT cells are part of the innate immune response, and are the first line of defense against tumors and viruses; they recognize infected cells by their down regulation of the major histocompatibility complex (MHC) class 1 molecules. NKT cells release cytokines and recruit other immune cells. (Pedroza-Pacheco et al., 2013)
Naïve T cell…

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