Heart attacks, specifically attacks caused by blockage within the coronary artery, cause severe injury to cardiac muscle cells. These injured cells then become deficient and eventually die. This occurrence spurs repair and regenerative responses that extract dead cells and cellular debris and recruits immune cells to form new blood vessels. The main constituents of this repair process are fibroblasts. Fibroblasts are able to convert into cardiac endothelial cells through the activity of transcription factor p53. The human heart consists of myocytes and non-myocytes. The non-myocytes include cardiac fibroblasts and endothelial cells which generate growth factors and extracellular matrix (ECM) proteins which are responsible for sustaining the
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With the field of science ever changing, it is crucial to be “in the know” of new developments as they are discovered. In order to do this, people need to utilize previously held knowledge in the subject of cell biology. For example, understanding how specific signaling proteins are used to allow cells to communicate with one another could quite possibly be the key to understanding how p53 is able to help transform fibroblasts into endothelial cells. Likewise, having background knowledge in the process of proteins being translocated exactly to the place where they are needed via a pre-sequence that is recognized by specific entities, (matrix processing protease for instance), and are then able to complete the task they were created for could be vital to understanding why certain functions of mitochondria happen the way they do. Cell biology is such an intricate and complex subject that it almost always depends on background knowledge in several subjects in order to piece together a completely separate process. The subjects discussed in this article depend heavily on topics not even touched on (the process of p53’s synthesis, for example) and therefore it is imperative to remember that the subjects within this discipline rely heavily on one another. The complexities of cellular biology cannot be fully appreciated unless they are viewed from an all-inclusive standpoint; that is, almost every process studied is influenced by another and should be treated as
With the field of science ever changing, it is crucial to be “in the know” of new developments as they are discovered. In order to do this, people need to utilize previously held knowledge in the subject of cell biology. For example, understanding how specific signaling proteins are used to allow cells to communicate with one another could quite possibly be the key to understanding how p53 is able to help transform fibroblasts into endothelial cells. Likewise, having background knowledge in the process of proteins being translocated exactly to the place where they are needed via a pre-sequence that is recognized by specific entities, (matrix processing protease for instance), and are then able to complete the task they were created for could be vital to understanding why certain functions of mitochondria happen the way they do. Cell biology is such an intricate and complex subject that it almost always depends on background knowledge in several subjects in order to piece together a completely separate process. The subjects discussed in this article depend heavily on topics not even touched on (the process of p53’s synthesis, for example) and therefore it is imperative to remember that the subjects within this discipline rely heavily on one another. The complexities of cellular biology cannot be fully appreciated unless they are viewed from an all-inclusive standpoint; that is, almost every process studied is influenced by another and should be treated as