Cause And Effect Of Alcoholic Liver Disease Essay
Alcoholic liver disease is the second largest liver disease after the infectious liver disease. Health risks and social threats induced from long-term excessive alcohol consumption are serious worldwide public health problems.
Heavy consumption of alcohol is well known to be associated with liver damage. The close relation between ethanol and liver damage is mainly due to the fact that about 80% of ingested alcohol is metabolized in the liver. Ethanol (EtOH) is metabolized into cytotoxic acetaldehyde by the enzyme alcohol dehydrogenase (ADH) in the liver. Ethanol is metabolized via a series of catabolic metabolic pathways, including complex oxidation reactions in liver tissue [3, 4], and acetaldehyde is oxidized to acetate by aldehyde oxidase or xanthine oxidase, giving rise to reactive oxygen species (ROS) via cytochrome P450 2E1 (CYP 2E1) .
Experimental animals exposed to alcohol display biochemical signs of hepatotoxicity and oxidative damage, suggesting a possible role of free radicals in causing some of the toxic effects of alcohol . Excessive alcohol consumption not only enhances ROS generation, but also depletes antioxidants, thus creating a state of oxidative stress that leads to severe liver injury . EtOH oxidation generates toxic metabolites and free radicals and induces a state of oxidative stress characterized by an enhancement of lipid peroxidation and a reduction in the activities of endogenous antioxidant enzymes such as superoxide…