Localization of Antidiabetic Potential of Cassia Tora Linn. Seeds
Abstract
Cassia tora Linn. is the wild medicinal plant and grows in most parts of India as weeds. In traditional literature, it is found that seeds of Cassia tora Linn. were used as folk medicine for the treatment of Diabetes in different parts of the world. In preliminary phytochemical investigations methanolic extract showed positive tests to sterols, carbohydrates, flavanoids, phenolic compounds, saponins and anthraquinine glycosides. Methanolic extract from the seeds of Cassia tora Linn. were investigated for their antidiabetic potential . Pharmacological in-vivo studies of antidiabetic activity of methanolic extract were evaluated with alloxan induced diabetic rats and normal rats. The result of antidiabetic potential suggested that methanolic extract possess antidiabetic activity. Methanolic extract processed through bioactive fractionation as water soluble fraction and ethyl acetate fraction. The phytochemical investigation and antidiabetic activities was carried out on …show more content…
drug (Metformin Hydrochloride)
(iv) Alloxan + Test extract treated rats 50 mg/kg
(v) Alloxan + Test extract treated rats 100mg/kg
(vi) Alloxan + Test extract treated rats 200mg/kg
The extracts were studied at three dose levels, 50 mg/kg, 100 mg/kg, and 200 mg/kg respectively. The extract was weighed according to the dose and diluted in the 2% PVP Solution.
Metformin hydrochloride was used as reference drug for evaluating the antidiabetic activity. The powdered drug was weighed (10mg) and made suspension in distilled water in 2% PVP Solution. Group-1 kept as normal healthy control, group-2 received orally standard drug as metformin hydrochloride, group-3, group-4 and group-5 received orally methanolic extract of 50 mg/kg, 100mg/kg, and 200mg/kg respectively. The rats were fasted for 15hrs. prior to experiment. The blood samples were withdrawn
Abstract
Cassia tora Linn. is the wild medicinal plant and grows in most parts of India as weeds. In traditional literature, it is found that seeds of Cassia tora Linn. were used as folk medicine for the treatment of Diabetes in different parts of the world. In preliminary phytochemical investigations methanolic extract showed positive tests to sterols, carbohydrates, flavanoids, phenolic compounds, saponins and anthraquinine glycosides. Methanolic extract from the seeds of Cassia tora Linn. were investigated for their antidiabetic potential . Pharmacological in-vivo studies of antidiabetic activity of methanolic extract were evaluated with alloxan induced diabetic rats and normal rats. The result of antidiabetic potential suggested that methanolic extract possess antidiabetic activity. Methanolic extract processed through bioactive fractionation as water soluble fraction and ethyl acetate fraction. The phytochemical investigation and antidiabetic activities was carried out on …show more content…
drug (Metformin Hydrochloride)
(iv) Alloxan + Test extract treated rats 50 mg/kg
(v) Alloxan + Test extract treated rats 100mg/kg
(vi) Alloxan + Test extract treated rats 200mg/kg
The extracts were studied at three dose levels, 50 mg/kg, 100 mg/kg, and 200 mg/kg respectively. The extract was weighed according to the dose and diluted in the 2% PVP Solution.
Metformin hydrochloride was used as reference drug for evaluating the antidiabetic activity. The powdered drug was weighed (10mg) and made suspension in distilled water in 2% PVP Solution. Group-1 kept as normal healthy control, group-2 received orally standard drug as metformin hydrochloride, group-3, group-4 and group-5 received orally methanolic extract of 50 mg/kg, 100mg/kg, and 200mg/kg respectively. The rats were fasted for 15hrs. prior to experiment. The blood samples were withdrawn