The Genain Quadlets Case Studies

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Sneha Ganguly- 1313249
Keerthana Ullas- 1313231
Hitha Maureen- 1313228
Sneha Elizabeth- 1313249

The Genain quadruplets (born in 1930) are a set of identical quadruplet sisters. All four of them developed schizophrenia, suggesting a major genetic factor to the cause of the disease. The pseudonym Genain, used to protect the identity of the family, comes from the Greek, meaning dire birth. The sisters were given the aliases Nora, Iris, Myra and Hester, to speak to each of the four letters in NIMH, the acronym for the United States National Institute of Mental Health. Nora, Iris, and Hester were hospitalized for their schizophrenia at least once.
The Genain quadruplets
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Schizoaffective disorder--a person shows both symptoms of both schizophrenia and a major mood disorder like depression.


1. Lack of social interest: People with schizophrenia usually hate socializing. They avoid eye to eye contact, cannot express themselves, and can rarely initiate a conversation with another person. They might also avoid responding if someone tries to have a conversation with them. This form of social withdrawal may be because they have an imaginary world that appears to be more real to them.
2. Delusion: Psychological health gets affected in a way that the person may start believing unrealistic things like they’re being harassed or being caught up in a catastrophic event.

3. Loss of appetite: Patients with schizophrenia deviate from normal behaviours in several aspects. One of them is the loss of appetite.

4. Hallucinations: In most cases, patients complain about hearing or visualizing things or experiencing weird sensations around them that do not exist to the normal world. They constantly keep feeling that they’re being controlled by powerful, unknown
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There are many newer antipsychotic medications available since the 1990’s, including Seroquel, Risperdal, Zyprexa and Clozaril. Some of these medications may work on both the serotonin and dopamine receptors, thereby treating both the “positive” and “negative” symptoms of schizophrenia. Other newer antipsychotics are referred to as atypical antipsychotics, because of how they affect the dopamine receptors in the brain. These newer medications may be more effective in treating a broader range of symptoms of schizophrenia, and some have fewer side effects than traditional antipsychotics. Learn more about the atypical antipsychotics used to help treat schizophrenia.
Coping Guidelines for the Family:
• Establish a daily routine for the patient to follow.
• Help the patient stay on the medication.
• Keep the lines of communication open about problems or fears the patient may have.
• Understand that caring for the patient can be emotionally and physically exhausting. Take time for yourself.
• Keep your communications simple and brief when speaking with the patient.
• Be patient and calm.
• Ask for help if you need it; join a support group.

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