Case Study Of Chlamydia

1133 Words 5 Pages
Developing and piloting approaches for the valuation of outcomes associated with sexually transmitted diseases.
A summary of work undertaken to date and plans for the future
1. Background
Chlamydia is a sexually transmitted infection (STI) caused by the bacterium Chlamydia trachomatis. It is the commonest STI of bacterial origin, globally and in the United Kingdom (UK) (World Health Organisation, 2008). In 2014, Chlamydia was the most commonly diagnosed STI in the UK, with 47% of diagnoses, and the prevalence is 3 to 6 percent amongst sexually active individuals aged 15 to 25 years (Public Health England, 2015). In 2014, approximately 210,000 people in England tested positive for Chlamydia; 67% of them were less than 25 years old (Public
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In order to accurately measure the benefits of chlamydia interventions, it is important to identify and value health states associated with the infection and its complications (Jackson et al, 2014). However, the valuation of health states for STIs such as Chlamydia, has several difficulties. A recent study (Jackson et al, 2014) identified the challenges associated with health states valuation for Chlamydia to include:
• The variation in the duration of its health states (infertility might be a permanent health state while the infection itself and complications like ectopic pregnancy and pelvic inflammatory diseases (PID) are temporary health states);
• The asymmetric nature of the disease burden with women most often affected more than men;
• The uncertainty surrounding its natural history;
• The issue of time preference as some of the complications occur months and sometimes years
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This requires appropriate information on the HSUVs. The objectives of this thesis are:
1. To develop approaches for the measurement and valuation of the outcomes associated with Chlamydia and
2. To pilot these approaches.
This will be achieved by:
i) Conducting reviews of the literature on the challenges associated with health state valuation of Chlamydia infection and its sequelae, focusing on:
• The methodology used for health state valuation and how previous studies have valued temporary health states (THS) for diseases and interventions;
• The issue of time preference in health state valuation and how previous studies have handled it; ii) Developing approaches for measuring the outcomes associated with Chlamydia based on the result of the review; iii) Piloting the approach/approaches on a representative population.

2. Progress to date
To date, a literature review and a systematic review have been conducted leading to chapters two and three.
Thesis structure

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