Abstract
A bone fracture is one of the most common large organ injuries to occur to humans and animals alike. When a bone is fractured, a unique and thorough regeneration of tissue takes place to repair it. There are two types of ways that a bone fracture can be repaired: direct bone healing is when the bones are intervened and set into place to allow for repair, indirect bone healing is allowing the fracture to heal naturally without any intervention from a third party. This paper will review the biology of a fracture and how stem cells and ossification processes coordinate with indirect and direct fracture healing of the bone.
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Introduction
Bone is a living tissue …show more content…
Both processes involve directly re-establishing an anatomically correct bone structure. Contact bone healing can only occur when an anatomical restoration of the fracture is done and rigid fixation of the fragments are provided so an interfragmentary strain can be avoided. The bone on both sides of the cortex must be made to re-establish the mechanical continuity. If the gap between bone ends is 0.01 mm or less and interfragmentary strain is less than 2%, the fracture can be united by so-called contact healing. (Marsell, 2012) One of the consequences of this can be the formation of cones or cavities in the gaps. These cavities can be later filled by bone that is produced by osteoblasts. This allows for the simultaneous regeneration of a bony union and restores the Haversian systems. The bridging osteons made by the osteoblasts later mature by remodeling into lamellar bone which then results in a successful fracture healing without periosteal callus …show more content…
There are many ways to heal a fractured bone but with the assistance of osteocytes, MSCs, and the formation of hematomas in the marrow, allow for the possibility to full recover from trauma such as this and return to full mechanical function and potential. There are still underlying issues of when bones are not properly placed to allow for successful remodeling but further study is needed in order to prevent issues such as interfragmentary strain. The above facts represent a basic knowledge of what we know when a fracture is detected in the body and how the body restores itself whether it’d be by intervention or not. With this knowledge, researchers have limitless possibilities in designing treatments for complex fractures. Interfragmentary strains can potentially be abolished once there is further study done on direct healing. If anything else, these steps should be able to provide sufficient motivation for the understanding of the biology of fracture
A bone fracture is one of the most common large organ injuries to occur to humans and animals alike. When a bone is fractured, a unique and thorough regeneration of tissue takes place to repair it. There are two types of ways that a bone fracture can be repaired: direct bone healing is when the bones are intervened and set into place to allow for repair, indirect bone healing is allowing the fracture to heal naturally without any intervention from a third party. This paper will review the biology of a fracture and how stem cells and ossification processes coordinate with indirect and direct fracture healing of the bone.
______________________________________________________________________________
Introduction
Bone is a living tissue …show more content…
Both processes involve directly re-establishing an anatomically correct bone structure. Contact bone healing can only occur when an anatomical restoration of the fracture is done and rigid fixation of the fragments are provided so an interfragmentary strain can be avoided. The bone on both sides of the cortex must be made to re-establish the mechanical continuity. If the gap between bone ends is 0.01 mm or less and interfragmentary strain is less than 2%, the fracture can be united by so-called contact healing. (Marsell, 2012) One of the consequences of this can be the formation of cones or cavities in the gaps. These cavities can be later filled by bone that is produced by osteoblasts. This allows for the simultaneous regeneration of a bony union and restores the Haversian systems. The bridging osteons made by the osteoblasts later mature by remodeling into lamellar bone which then results in a successful fracture healing without periosteal callus …show more content…
There are many ways to heal a fractured bone but with the assistance of osteocytes, MSCs, and the formation of hematomas in the marrow, allow for the possibility to full recover from trauma such as this and return to full mechanical function and potential. There are still underlying issues of when bones are not properly placed to allow for successful remodeling but further study is needed in order to prevent issues such as interfragmentary strain. The above facts represent a basic knowledge of what we know when a fracture is detected in the body and how the body restores itself whether it’d be by intervention or not. With this knowledge, researchers have limitless possibilities in designing treatments for complex fractures. Interfragmentary strains can potentially be abolished once there is further study done on direct healing. If anything else, these steps should be able to provide sufficient motivation for the understanding of the biology of fracture