6.1 RESULTS
6.1.1 Barrier Effects on Choice Behavior
Over training days (i.e., Discrimination phase III), the mice came to choose the arm containing the Higher reward (HR arm) on a majority of trials in the absence of a barrier (Day effect: F (5, 40) = 4.7, p <0.001). Without the barrier, the mice chose the HR arm more often on the third day of training in comparison to the first training day (Fisher’s PLSD, p <0.001). When the 20-cm barrier was placed in the HR arm, the number of HR arm choices significantly decreased. Specifically, the mice chose the HR arm less on the first day of training with the barrier in comparison to the second and third days of training without the barrier (Fisher’s PLSD, p < 0.001 and 0.0001, respectively). On the third day of training with the 20-cm barrier, the mice chose the LR arm with greater frequency than they did on the first day of such training (Fisher’s PLSD, p <0.001), but with less frequency than they did on the third day of training without the barrier (Fisher’s PLSD, p < 0.001). On the first day of testing with the 20-cm …show more content…
Arm Choice b. Response Latency
Figure 5: Effect of Bromocriptine on T-maze performance
a. Effect of i.p. administration of DA agonist Bromocriptine on arm choice in the maze. Mean (±SEM) number of barrier arm choices after treatment with vehicle or various doses of bromocriptine are shown. Regression analysis revealed that there was a significant linear relation between dose and arm choice [F (1.491, 7.454) = 57.78, p<0.0001; r2=0.04775].
b. Effect of i.p. administration of DA agonist Bromocriptine on response latency in the maze. Mean (+SEM) response latency (i.e., average across 10 trials, expressed in seconds) after treatment with vehicle or Bromocriptine are shown. Repeated measures ANOVA indicated an overall significant effect of drug treatment on response latency [F (1.973, 9.866) = 654.4, p<0.0001; r2=0.003219].
6.1.3 Effect of
6.1.1 Barrier Effects on Choice Behavior
Over training days (i.e., Discrimination phase III), the mice came to choose the arm containing the Higher reward (HR arm) on a majority of trials in the absence of a barrier (Day effect: F (5, 40) = 4.7, p <0.001). Without the barrier, the mice chose the HR arm more often on the third day of training in comparison to the first training day (Fisher’s PLSD, p <0.001). When the 20-cm barrier was placed in the HR arm, the number of HR arm choices significantly decreased. Specifically, the mice chose the HR arm less on the first day of training with the barrier in comparison to the second and third days of training without the barrier (Fisher’s PLSD, p < 0.001 and 0.0001, respectively). On the third day of training with the 20-cm barrier, the mice chose the LR arm with greater frequency than they did on the first day of such training (Fisher’s PLSD, p <0.001), but with less frequency than they did on the third day of training without the barrier (Fisher’s PLSD, p < 0.001). On the first day of testing with the 20-cm …show more content…
Arm Choice b. Response Latency
Figure 5: Effect of Bromocriptine on T-maze performance
a. Effect of i.p. administration of DA agonist Bromocriptine on arm choice in the maze. Mean (±SEM) number of barrier arm choices after treatment with vehicle or various doses of bromocriptine are shown. Regression analysis revealed that there was a significant linear relation between dose and arm choice [F (1.491, 7.454) = 57.78, p<0.0001; r2=0.04775].
b. Effect of i.p. administration of DA agonist Bromocriptine on response latency in the maze. Mean (+SEM) response latency (i.e., average across 10 trials, expressed in seconds) after treatment with vehicle or Bromocriptine are shown. Repeated measures ANOVA indicated an overall significant effect of drug treatment on response latency [F (1.973, 9.866) = 654.4, p<0.0001; r2=0.003219].
6.1.3 Effect of