Cardiac Dysfunction

Improved Essays
Cardiac dysfunction is the most severe side effect of DOX therapy. Previous studies demonstrate that cardiomyocyte death through apoptosis, necrosis, and other forms is a primary contributor to the development of DOX-induced cardiomyopathy(Zhang et al.,2009) The anthracycline doxorubicin-induced myocyte apoptosis is mediated by oxy radical chemistry. and change in level of antioxidant in the heart tissues(increase in CAT ,SOD and decrease level of GSH).

On the other hand, a significant increase was observed in GSH levels, SOD and CAT activities in liver in the group that was given DOX and omega-3. This might indicate that omega-3 have a protective effect against DOX-induced oxidative damage. omega-3 treatment prevents oxidative damage. Takayama et al. (2010) reported that hepatic antioxidant enzymes increased, while hepatic lipid peroxide concentrations prominently
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From previous studies, fish oil omega-3 consumption is known to be associated with heart failure.(Mozaffarian et al.,2005; Teng et al.,2010) It has been reported that γ-linolenic acid had cardioprotective properties against DOX-induced cardiotoxicity. Chakrabarti et al .,(2001) Some hypotheses have been suggested to explain the mechanism responsible for the beneficial effect of fish oil omega-3 fatty acids.

Fish oil omega-3 fatty acids could be mediated by the replacement of anthracycline-peroxidized fatty acids in lipid-containing structures such as membranes, Hrelia et al .,(2001) by recovery of an imbalance of the cytokine network or by alterations in eicosanoid metabolic pathways. Matsui rt al., (2002) Recent studies have shown that dietary supplementation with omega-3 from fish oil have the potential to attenuate the detrimental effect of a number of cardiac

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