Burn Injury Essay

Burn injury is a common type of traumatic injury, causing considerable morbidity and mortality. The after-effects of burns not only handicap the patient and leave psychological trauma but also impose huge economic burden on the victim's family and society in general (Yao et al., 2011). An extensive burn profoundly affects the patient's physique, psyche, financial situation and socio-cultural dynamics of the family. Patients with extensive burns frequently die, and for those with lesser injury, physical recovery is slow and painful as well (Shrivastava and Shrivastava, 2012). The local and systemic inflammatory response to thermal injury is extremely complex, resulting in both local burn tissue damage and deleterious systemic effects on all other organ systems distant from the burn area itself. Thermal injury initiates systemic inflammatory reactions producing burn toxins and oxygen radicals and finally leads to peroxidation. The injured tissue initiates an inflammation-induced hyperdynamic, hypermetabolic state that can lead to severe progressive distant organ failure. Multiple organ failure (e.g., cardiac instability, respiratory or renal failure) and immune dysfunction remain major causes of burn morbidity and mortality (Çakir and Yeğen, 2004). The forensic …show more content…
The purpose of histopathological study was to determine progressive skin changes in burn injuries with serial biopsies up to the end of the 2nd week with particular interest of the timing of burn injury and also, to investigate the time course of infiltrated leucocytes and their relationship with injury severity, while the immunohistochemical study emphasized the post-burn effects on T lymphocyte subsets (CD4+ and CD8+ cells) in an attempt to reveal their role in immunosuppression and their relation to time and severity of