First, is the presence of neuritic plaques which contain excess deposits of B-amyloid protein. The B-amyloid fragments clump together into plaques that impair the function of nerve cell in the brain. Second brain change is neurofibrillary tangles in the cortex which causes the microtubules to disintegrate and collapse the neuron’s transport system. These brain changes lead to a loss or degeneration of neurons and synapses, especially within the neocortex and hippocampus. Reduction in serotonin receptors, serotonin uptake into platelets, production of acetylcholine in the areas of the brain in which plaques and tangles are found, acetylcholinesterase, and choline acetyl-transferase are also changes in neurotransmitter systems associated with Alzheimer’s …show more content…
The knowledge of the causes, sign and symptoms of the disease is important when dealing with Mr. Jones properly. It is also very important that as a nurse I am knowledgeable about the triggers of this disease and how to eliminate those triggers since he is living in the facility. Knowledge of the 10 rights of medication administration and how to use the different kinds of inhalers that might be use by the resident. Lastly, as a nurse, I must have a competency knowledge with regard to my scope of practice that way I will know my limitations in dealing with Mr.