To me the lost colony basically set up for doom all the way from the beginning, they were already struggling settling in a new place with barley any resources. Something was going to eventually happen to them. Even though no one really knows what really happen to them somehow they all disappeared or there was no trace of what happened to the Lost colony.
The lost colony was made up men, women, and children that came to Roanoke island with the permission from the queen at that time, queen Elizabeth I to establish a permanent settlement in the new world. Their leader John white was sailing back to England to get fresh supplies not knowing when he gets back that a war or conflict would break out between the English and the Spanish.