Breast Ovarian Syndrome : A Look Into A Case Study Essay
Polycystic ovarian syndrome (aka PCOS) is a disorder that is expected in patients with irregular menses, acne, seborrhea, hirsutism, infertility, and alopecia. PCOS has recently been associated with the metabolic syndrome. Patients may develop obesity, insulin resistance, type 2 diabetes, hypertension, liver disease, and sleep apnea. Clinical diagnosis would include hematological and radiological tests. Management would be a combined effort between a patient’s dermatologist, endocrinologist, gynecologist, and nutritionist. Long term medications and lifestyle changes are essential for a successful outcome. This case study focused on the understanding of the normal and abnormal endocrine functions involved in the pathogenesis of PCOS.
Role of Insulin
Insulin plays an important role in the normal ovarian cycle. It enhances the amplitude of LH pulses. In the liver, increased insulin levels inhibit production of sex hormone binding globulin. It inhibits hepatic production of IGFBP-1 which results in increased levels of circulating IGF-1 (Insulin like growth factor 1) levels. It binds to the IGF-1 receptors on the ovary and directly stimulates androgen production. [sup](see below for sited sources)
There is an increase in the frequency and amplitude pulse which results in elevated levels of LH. However, whether this change in LH secretion is due to a defect of the hypothalamus or due to external factors…