dded (a sub-process called ossi fi cation or bone formation). Remodeling involves continuous removal of discrete packets of old bone, replacement of these packets with newly synthesized proteinaceous matrix, and subsequent mineralization of the matrix to form new bone (FernándezTresguerres-Hernández-Gil et al. 2006; Fraher
1993) . These processes also control the reshaping or replacement of bone during growth and following injuries like fractures but also microdamage (prevents accumulation of bone microdamage through replacement of old bone with the new one) (Turner 1998) which occurs during normal activity. Remodeling responds also to functional demands of the mechanical loading. As a result, bone is added where needed and removed where …show more content…
This process is essential in the maintenance of bone strength and mineral homeostasis. The skeleton is a metabolically active organ that undergoes continuous remodeling throughout life. This remodeling is necessary both to maintain the structural integrity of the skeleton and to subserve its metabolic functions as a storehouse of calcium and phosphorus.
Normal bone remodeling cycle requires that the process of bone resorption and bone formation take place in a coordinated fashion, which in turn depends on the orderly development and activation of osteoclasts and osteoblasts, respectively. This property of bone, which constantly resorbs the old bone and forms new bone, makes the bone a very dynamic tissue that permits the maintenance of bone tissue, the repair of damaged tissue, and the homeostasis of the phosphocalcic metabolism. The bone remodeling cycle involves a series of highly regulated steps that depend on the interactions of two cell lineages, the mesenchymal osteoblastic lineage and the hematopoietic osteoclastic lineage (Fraher 1993) .
The
1993) . These processes also control the reshaping or replacement of bone during growth and following injuries like fractures but also microdamage (prevents accumulation of bone microdamage through replacement of old bone with the new one) (Turner 1998) which occurs during normal activity. Remodeling responds also to functional demands of the mechanical loading. As a result, bone is added where needed and removed where …show more content…
This process is essential in the maintenance of bone strength and mineral homeostasis. The skeleton is a metabolically active organ that undergoes continuous remodeling throughout life. This remodeling is necessary both to maintain the structural integrity of the skeleton and to subserve its metabolic functions as a storehouse of calcium and phosphorus.
Normal bone remodeling cycle requires that the process of bone resorption and bone formation take place in a coordinated fashion, which in turn depends on the orderly development and activation of osteoclasts and osteoblasts, respectively. This property of bone, which constantly resorbs the old bone and forms new bone, makes the bone a very dynamic tissue that permits the maintenance of bone tissue, the repair of damaged tissue, and the homeostasis of the phosphocalcic metabolism. The bone remodeling cycle involves a series of highly regulated steps that depend on the interactions of two cell lineages, the mesenchymal osteoblastic lineage and the hematopoietic osteoclastic lineage (Fraher 1993) .
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