Clinical trials were conducted on persons of ages 18 and older, inclusive of both males and females. Participants who were selected were characterized as obese or overweight, measured using the body mass index of 25kg/m² or greater. It was noted that all patients were otherwise healthy individuals, in that they did not have any bodily disease that affected metabolism of calcium and particularly BMD. BMD has been utilized as an accurate measurement for bone health as well as one of many critical indicators of fracture risk and mortality. The clinical trials recorded the total hip BMD, lumbar spine BMD, and total body BMD using dual-energy x-ray absorptiometry (DXA). This advanced x-ray technology is a noninvasive procedure that exposes the body to ionizing radiation, producing an image of the desired bone structure. The hip and spinal regions, the structures that’s were scanned, have a large amount of surface area, making them vulnerable to changes in bone metabolism and fractures. Patients placed on specific dietary regiments were called in at intervals of 2, 3, 6, 12, and 24 months with their detailed food journals. Results of the clinical trials determined that there was a significant decrease in total hip BMD, and therefore a significant decrease in total body BMD at the 6 month …show more content…
Several studies in the past have focused on the physical, mental, and social effects of weight loss on females. Numerous reports have verified that women lose on average four times as much BMD than men of similar health conditions. Furthermore, results revealed that postmenopausal women had significant loss in BMD than women who maintained their body weight. This indicates that women overall are at a much higher risk for getting hip fractures, which can lead to childbirth complications [for premenopausal women]. Still, not many trials have been conducted to investigate the effects of weight loss on specific anatomical BMDs [such as the spine or femur] in men. In order to observe whether or not bone integrity was preserved and to what extent, a study was conducted to understand the effect of dietary restrictions on men who are either overweight or obese. The controlled study recruited 38 men [50-60 years of age, average weight of 31.9kg/m² ± 4.4 standard body mass index] to undergo voluntary weight loss through a restricted diet or through weight maintenance. The volunteers were otherwise healthy individuals and were contacted regularly throughout the duration of the experiment to keep track of all supplements, vitamins, and physical activity that accompanied the diet plan. After a 6 month period of this regiment, data from the two trials was compared.