Blood Brain Barrier Case Study

1595 Words 7 Pages
Scientific Background and Long-term Objectives Blood brain barrier (BBB) is a selectively permeable membrane that controls the passage of substances from the bloodstream to the central nervous system (CNS).Poor penetration of the drugs with various compositions across the BBB is evident in the biomedical research. This impacted greatly the pharmaceutical interventions of various neurodegenerative disorders, brain tumours and impairment of the CNS [1].BBB is the main route for the therapeutic compounds targeted to the brain. But, majority of the neuro-medicines, transporter ligands and hydrophilic (water loving) molecules have less permeability across this region [1]. Nanocarriers (size 1-100nm) are defined as carriers being used to transport …show more content…
Side-effects, safety and reversibility would be monitored continuously. BBB itself could act as the CNS drug source. If BBB becomes leaky, it allows immune cells entry to the CNS. Nevertheless, the immune cell passage across BBB is regulated and leakage acts as by-product of the immune cells trafficking. The luminal surface does not necessitate passage across BBB and thereby, targeting peripheral tissues are highly effective to almost half of BBB. The luminal receptors, which stimulate endothelial cells of the brain, are readily targetable …show more content…
Supervising committee will be structured so that they can help us in the execution of the project. Experiments planned will provide drug based designing training along with knowledge of lipid chemistry. The students involved will also be trained well in brain theories and will be monitored by supervisors.


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