Blood Brain Barrier Case Study
Side-effects, safety and reversibility would be monitored continuously. BBB itself could act as the CNS drug source. If BBB becomes leaky, it allows immune cells entry to the CNS. Nevertheless, the immune cell passage across BBB is regulated and leakage acts as by-product of the immune cells trafficking. The luminal surface does not necessitate passage across BBB and thereby, targeting peripheral tissues are highly effective to almost half of BBB. The luminal receptors, which stimulate endothelial cells of the brain, are readily targetable …show more content…
Supervising committee will be structured so that they can help us in the execution of the project. Experiments planned will provide drug based designing training along with knowledge of lipid chemistry. The students involved will also be trained well in brain theories and will be monitored by supervisors.
1. Gan L, Wang J, Jiang M, Bartlett H, Ouyang D, Eperjesi F,Gan,Y. 2013. Drug discovery today 18:290-297.
2. Nicolas J, Mura S, Brambilla D, Mackiewicz N, Couvreur P. 2013. Chemical Society Reviews, 42: 1147-1235.
3. Kumari A, Yadav SK, Yadav SC. 2010. Colloids and Surfaces B: Biointerfaces, 75:1-18.
4. Yavlovich A, Smith B, Gupta K, Blumenthal R,Puri A. 2010. Molecular membrane biology, 27: 364-381.
5. Ganta S, Devalapally H, Shahiwala AF, Amiji M.2008. Journal of Controlled Release,126:187-204.
6. Mura S, Nicolas J, Couvreur P. 2013. Nature materials, 12:991-1003.
7. Li X, Qian Y, Liu T, Hu X, Zhang G, You Y, Liu S. 2011. Biomaterials, 32: 6595-6605.
8. Lu CT, Zhao YZ, Wong HL, Cai J, Peng L,Tian, XQ. 2014. Dovepress,9:2241-2257.
9. Tosi J, Ruozi B, Carbone C, Balletti D, Pignatello R, Vandelli MG, Puglisi G. 2016. Journal of Drug Delivery Science and