Evaluate the effect oral administration of Bisphenol A on tissue and liver enzymes, serum lipids and blood glucose in rats
Abstract:
Background and Purpose:Bisphenol A (BPA) is a synthetic compound of carbon with chemical formula is (CH3)2C (C6H4OH) 2 Diphenyl methane derivatives belonging to the group. BPA has harmful effects on mammals.Because of endocrine disrupters can be on serum lipids, tissue and serum liver enzymes and blood sugar affect, the aim of this study was to evaluate the effects of BPA on serum lipids, tissue and liver enzymes and blood sugar serum.
Materials and methods:In this experimental study, 20 adult male rats were used, weighing approximately 220-300.Animals were divided into 4 groups of 5.1. The control group (intact …show more content…
The effect of oral administration of Bisphenol A (BPA) on serum glucose
Cut that is made in the liver. Groups of control and no change was observed in the tissues. Destruct in the cytoplasm and the nucleus of hepatocytes was observed in normal mode (figure 4).
BPA administered at a dose of 50 mg/kg/dayincreases hepatocyte polymorphism can be seen in comparison to other groups.Sinusoids with eosinophilic the cytoplasm and expansion than other groups under study. (figure 6).
100X magnification at coloring H/E Normal liver(control)(figure 4). 100X magnification at coloring H/E Normal liver(positive control)(figure 4).
100X magnification at coloring H/E in dose 5 mg/kg/day (figure 5). 100X magnification at coloring H/E in dose 50 mg/kg/day (figure 6).
Discussion and conclusion:
According to the results of this study in which doses of 5-50 mg/kg/day Bisphenol water for 2 weeks had a significant decrease in Amount liver enzymes AST, ALT and ALP were observed compared to The control group. The difference between high and low dose groups, which have taken no significant differences existed.It seems like Bisphenol …show more content…
Administration with high and low doses of Bisphenol A no significant changes in serum total cholesterol, HDL serum and serum glucose levels did not change, but LDL cholesterol was significantly
Abstract:
Background and Purpose:Bisphenol A (BPA) is a synthetic compound of carbon with chemical formula is (CH3)2C (C6H4OH) 2 Diphenyl methane derivatives belonging to the group. BPA has harmful effects on mammals.Because of endocrine disrupters can be on serum lipids, tissue and serum liver enzymes and blood sugar affect, the aim of this study was to evaluate the effects of BPA on serum lipids, tissue and liver enzymes and blood sugar serum.
Materials and methods:In this experimental study, 20 adult male rats were used, weighing approximately 220-300.Animals were divided into 4 groups of 5.1. The control group (intact …show more content…
The effect of oral administration of Bisphenol A (BPA) on serum glucose
Cut that is made in the liver. Groups of control and no change was observed in the tissues. Destruct in the cytoplasm and the nucleus of hepatocytes was observed in normal mode (figure 4).
BPA administered at a dose of 50 mg/kg/dayincreases hepatocyte polymorphism can be seen in comparison to other groups.Sinusoids with eosinophilic the cytoplasm and expansion than other groups under study. (figure 6).
100X magnification at coloring H/E Normal liver(control)(figure 4). 100X magnification at coloring H/E Normal liver(positive control)(figure 4).
100X magnification at coloring H/E in dose 5 mg/kg/day (figure 5). 100X magnification at coloring H/E in dose 50 mg/kg/day (figure 6).
Discussion and conclusion:
According to the results of this study in which doses of 5-50 mg/kg/day Bisphenol water for 2 weeks had a significant decrease in Amount liver enzymes AST, ALT and ALP were observed compared to The control group. The difference between high and low dose groups, which have taken no significant differences existed.It seems like Bisphenol …show more content…
Administration with high and low doses of Bisphenol A no significant changes in serum total cholesterol, HDL serum and serum glucose levels did not change, but LDL cholesterol was significantly