As well, anticonvulsant medication like valproate when combined with antipsychotic agents like olanzapine, risperidone, quetiapine would be beneficial in treating patient with severe manic episodes.
However, some data retrieved from multiple treatments meta-analysis of treatments for acute mania, suggested that medications like Haloperidol, risperidone and olanzapine would significantly work as a primary mood disorder (Cipriani et al., 2011). Furthermore, some randomized, double-blind, controlled studies suggested that olanzapine is more efficient in treating the manic episodes in Bipolar Disorder Tohen et al., 2003).
Also, another studies suggested that the use of Olanzapine as an adjunct therapy with wither Lithium or risperidone is more effective than using lithium as a monotherapy (Yatham et al., 2003). However, the limitation of use of Olanzapine is due to its serious side effect like weight gain, diabetes risk, hypertriglyceridemia and even …show more content…
In the same time, according to the National Guide Clearinghouse, the addition of anti-depressant like selective serotonin reuptake inhibitor (SSRI), serotonin norepinephrine reuptake inhibitor (SNRI), bupropion, and monoamine oxidase inhibitor (MAOI) would be helpful. However, we should monitor the patient who use such combination after adding anti-depressant medication for the sign and symptom of mania as the possibility of such anti-depressant medication would trigger manic episode (National Guideline Clearinghouse | VA/DoD clinical practice guideline for management of bipolar disorder in adults,