CRP Transgenic Mice: A Case Study

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Biological functions: The main biological functions for CRP to determine via its ability to identify pathogens and injured cells of the host and mediate their elimination via activating the complement system and phagocytic cells (Brundish and Baddiley,1968 ; Weiser et al., 1997). CRP binds to microorganisms and mediates their killing to more recent observations of protection against bacterial pathogens in CRP transgenic mice. The most significant evidence has supported the notion that CRP plays an important role in host defense. CRP mediates protection due it supports three main effector functions, firstly activation of complement, secondly the induction of phagocytosis and finally plays a key role in opsonization (Szalai, 2002a).
More relevant to the function of CRP is human secretory phospholipase A2 with CRP may serve to promote phagocytosis of injured cells and tissue debris, an enzyme secreted by liver as an acute phase protein
…show more content…
CRP recognition of phosphocholine on microorganisms which is play a key role in our protection against, a more significant role perhaps the binding CRP to PC in the injured membranes (Li et al., 1994).
The interaction of human CRP with cell wall polysaccharide (CWPS) has possibility to activate the classical complement pathway through interaction with C1q component, an activity which cannot be achieved via simple PC-bound (Volanakis, 1982). Binding of CRP to sugar phosphate is suggested to bind to occur via the carbohydrate component of the ligand in the area neighboring to the choline site, this area is as well proposed to bind glycerol of PC glycerol, both occurring by the OH group closest the phosphate (Lee et al.,

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