Some studies have shown that berberine has anti-cancer influences by inhibiting hepatocarcinogens. Berberine has been found to cause liver weight loss, c-glutamylTrans peptidase, glutamate pyruvate transaminase and bilirubin, all indications of liver damage caused by NDEA (N-nitrosodiethylamine, a strong hepatocarcinogen). Berberine treatment reduced glutathione-transferase levels in the liver, but only had a light effect on glutathione. Berberine reduces the 20-methylcholanthrene-induced sarcoma in mice, as it increases the lifespan compared to animals and reduces the number of animals with
