Baricitinib Research Paper

Decent Essays
Show More
Baricitinib is an inhibitor of JAK1 and JAK2 that helps with moderate to severe rheumatoid arthritis. JAK enzymes such as JAK1, JAK2, JAK3 and TYK2 are known to treat multiple inflammatory diseases (Pubchem, n.d.). Baricitinib is an oral, once daily treatment that shows high inhibition against the Janus kinases enzymes. Janus kinases are enzymes involved in immune function and inflammation activities. When Baricitinib is administered, the compound binds to JAK1 and JAK2 which prevents the activation of the 2 enzymes and inhibits the JAK signal transducers (Drugs.com, 2017). Also, Baricitinib reduces the propagation of JAK1 and 2 cells. It shows moderate to low inhibition against JAK3 and TYK2, respectively.
Rheumatoid Arthritis (RA) is a type

Related Documents

  • Improved Essays

    Cd20 Unit 4
    • 601 Words
    • 3 Pages

    Cd20 Unit 4

    Homework 4 1. A. Hcd19Tg is Human CD-19-Transgenic mice overexpressing CD19 which is a B-lymphocyte antigen present on all B cells. It is a transgenic model of human gene CD-19 introduced into the mice for research studying the effect of CD19 related to B-cell related immunological response B. CD1dloCD5+ is a rare phenotype of Regulatory B cells found in spleen of normal and autoimmune mice producing IL-10 and hence also called the B10 cells. As this phenotype is identifies to regulate T cell dependent inflammatory response, they are researched for role in myasthenia gravis and other neuro inflammatory diseases. C. Terbutaline is a B2 adrenergic receptor agonist causing vasodilation, smooth muscle relaxation and skeletal muscle contractions.…

    • 601 Words
    • 3 Pages
    Improved Essays
    Read More
  • Improved Essays

    Minoxidil Research Paper
    • 398 Words
    • 2 Pages

    Minoxidil Research Paper

    Minoxidil, an antihypertensive vasodilator medication, which was developed in the 1950’s by a company called Upjohn originally used to treat ulcers. During their experiments with dogs, they figured out that it did not cure ulcers, but acted as a vasodilator. Due to this recent discovery, Upjohn was able to develop a compound called Minoxidil in 1963 as well as being able to synthesize over 200 variations of the compound. The molecular structure and compound of Minoxidil is C9H15N50, made entirely of nonmetals with the molecular weight being 209.2483 g/mol, the UIPAC name being 3 hydroxy, 2 imino, 6 piperidin, 1 ylpyrimidin, and 4 amine. The percentage composition of carbon being 51.65, hydrogen being 7.24, nitrogen being 33.47, and oxygen being 7.64.…

    • 398 Words
    • 2 Pages
    Improved Essays
    Read More
  • Improved Essays

    Remicade Case Studies
    • 899 Words
    • 4 Pages

    Remicade Case Studies

    Therefore, the previous denial should be overturned. Findings: The member is a 59-year-old woman who carries the diagnosis of sero-negative Rheumatoid Arthritis (RA). The issue in this case is whether continued infliximab (Remicade) infusions 7 mg/kg every 6 weeks are medically…

    • 899 Words
    • 4 Pages
    Improved Essays
    Read More
  • Improved Essays

    Barium Enenema
    • 464 Words
    • 2 Pages

    Barium Enenema

    Numerous articles support either modality. The research will be based on the analysis of the different articles and criticising the validity of each argument. They both share similarities in the patient preparation. CT colonography as well as barium enema require bowel preparation, the bowel need to be free from any faeces as its presence can mimic pathology and impair diagnosis. CT colonography offers cross sectional images and allows three dimensional reconstruction.…

    • 464 Words
    • 2 Pages
    Improved Essays
    Read More
  • Decent Essays

    Buspirone Pros And Cons
    • 200 Words
    • 1 Pages

    Buspirone Pros And Cons

    Most of patients are prescribed from the benzodiazepine (anxiolytic) category such as Xanax or Klonopin for tension relief, reduction of other somatic symptoms, and relaxation (butcher, 2008). Benzadiazepines were released in the early 1960s and are the most widely used class of anti-anxiety medications. They are widely used because they are beneficially and work fast to cure acute anxiety. Depending on the dosage being taken the help quell anxiety and at higher dosages they act as sleep-inducing agents and can be used to treat insomnia (Butcher, 2008). Unfortunately some of the side affects include psychological and physiological dependence.…

    • 200 Words
    • 1 Pages
    Decent Essays
    Read More
  • Great Essays

    Evolocumab Research Paper
    • 1540 Words
    • 7 Pages

    Evolocumab Research Paper

    Michelle DeSanti Biology 22 (24556) Professor Linder 4 May 2017 Clinical outcomes: Evolocumab use for Cardiovascular Disease High cholesterol, two words that can certainly ignite a fear in a patient who is newly diagnosed with this common issue. Which brings us to the question, what exactly is high cholesterol and what makes it so bad? Low-density lipoprotein cholesterol, also known as LDL cholesterol is what many consider to be the “bad cholesterol”.…

    • 1540 Words
    • 7 Pages
    Great Essays
    Read More
  • Improved Essays

    Furosemide Research Paper
    • 417 Words
    • 2 Pages

    Furosemide Research Paper

    Furosemide is a medication known as a loop diuretic (Allen, 2013). A diuretic is a medication which increases the amount of urine that passes out from the kidneys and they are often referred to as water tablets. It works by eliminating water and salt from the body through urination. In the kidneys, salt and water are filtered out of the blood and into the tubules of the kidney to the Glomerulus (Waugh and Grant, 2014), making the filtered fluid into urine (Omudhome, 2014). The sodium, chloride and water that are filtered out of the blood is then reabsorbed back into the blood before being eliminated as urine (Omudhome, 2014).…

    • 417 Words
    • 2 Pages
    Improved Essays
    Read More
  • Improved Essays

    Fda Research Paper
    • 1369 Words
    • 6 Pages

    Fda Research Paper

    Food and Drug Administration FDA, http://www.fda.gov/forconsumers/consumerupdates/ucm397711.htm The Food and Drug Administration (FDA) is an agency that regulates food and supplements as well many more items. The FDA, provides an online website that provides information on numerous topics, like for example artificial sweeteners. With the help of the FDA, there is information provided to us the public. Through this website we know what artificial sweeteners are and if they are safe.…

    • 1369 Words
    • 6 Pages
    Improved Essays
    Read More
  • Decent Essays

    Ciprofloxacin Case Study
    • 285 Words
    • 2 Pages

    Ciprofloxacin Case Study

    In Selected Patient Populations (886) Patients with renal failure or liver disease As expected from differences in routes of elimination, for patients with poor or no renal function, changes in terminal half-life of elimination were greatest for ofloxacin (increased from 8 to 37 h) and moderate for norfloxacin, ciprofloxacin, and enoxacin (increases ranged from 4 to 5 h to 8 to 9 h) (Table 5), while no changes occurred for pefloxacin (506). Clearance by hemodialysis was 14% or less of simultaneous plasma clearance for norfloxacin (223), ciprofloxacin (708), ofloxacin (224), and enoxacin (546) and was 28% for pefloxacin (506). Peritoneal dialysis also contributed minimally to clearance of ciprofloxacin (230, 691) and ofloxacin (504).…

    • 285 Words
    • 2 Pages
    Decent Essays
    Read More
  • Decent Essays

    Brintellix: A Case Study
    • 283 Words
    • 2 Pages

    Brintellix: A Case Study

    On 2nd May 2016, the drug safety podcast of FDA made an announcement of a change in the brand name of anti-depressant drug Brintellix, so that it is not mistaken for anti-platelet drug Brilinta. The podcast was announced by Advanced Practice Nurse, Lesley Navin. She mentioned that the FDA aims to minimize prescription errors caused by similarity in the two drug brand names. Brintellix, manufactured by Takeda Pharmaceuticals will be renamed to Trintellix, beginning June 2016. Ms. Navin further mentioned that the remainder of the packaging and labelling of the drug will remain the same.…

    • 283 Words
    • 2 Pages
    Decent Essays
    Read More
  • Decent Essays

    Allopurinol Research Paper
    • 76 Words
    • 1 Pages

    Allopurinol Research Paper

    Normally allopurinol should be avoided when patients have gout attacks. It has been reported that it can make patients worse, especially at first. So we use colchicine instead as prophylactic drugs. Moreover, gradual titration the dose is recommended to get full effect. The patient should start allopurinol 100 mg daily then 100 mg increase per week until the uric acid level reach 6 mg/dl or lower but not over 800 mg which is the maximum dose.…

    • 76 Words
    • 1 Pages
    Decent Essays
    Read More
  • Improved Essays

    The Benefits Of Melanoma
    • 818 Words
    • 4 Pages

    The Benefits Of Melanoma

    These are types of protein, which is being injected into the T- cell of the immune system. T- Cell helps from the attack of other cells. These drugs boost the immune system which helps to fight against Melanoma. Many patients who had tested with these PD-1 inhibitors lived longer than expected. This is because PD-1 inhibitors “shrink tumors significantly in 15 to 50 percent of patients.”…

    • 818 Words
    • 4 Pages
    Improved Essays
    Read More
  • Improved Essays

    Barium Purification Methods
    • 123 Words
    • 1 Pages

    Barium Purification Methods

    There are so many ways that doctors as well people can test if you have cancer. I will tell you different ways that you can do that. I will tell you 25 ways that you can do this. These test I am going to talk about are ways doctors determine if you have cancer. A purification is a method that conveys fluid into the rectum and colon through the rear-end.…

    • 123 Words
    • 1 Pages
    Improved Essays
    Read More
  • Improved Essays

    N-Butyl Bromide Lab Report
    • 234 Words
    • 1 Pages

    N-Butyl Bromide Lab Report

    One important aspect of organic chemistry is the synthesis of new compounds. It is also important for chemists to understand how to perform certain techniques, such as extraction and distillation, to produce the new products, which are usually drugs and cures for illnesses. In this experiment, n-butyl bromide was produced. n-Butyl bromide is an alkyl halide, which are usually synthesized by an alcohol and an acid. In the case of n-butyl bromide, n-butyl alcohol was used along with sodium bromide and sulfuric acid.…

    • 234 Words
    • 1 Pages
    Improved Essays
    Read More
  • Improved Essays

    Nsb10 Unit 9 Lab Report
    • 876 Words
    • 4 Pages

    Nsb10 Unit 9 Lab Report

    In this equation, x and y denotes the number of moles of RE and Mn atoms per formula unit of the structure, respectively. The RE and Mn represent the theoretical magnetic moment of trivalent free RE3+ ions and divalent Mn2+ ions respectively. The experimental values of total magnetic moments were found to be smaller than the calculated values (Table xyz). The crystal field effects can lead to lower value of magnetic moments for RE3+ ions in these compositions as compared to free RE3+ ions, which in turn could lower the total magnetic moment of these compositions. This discrepancy in the total magnetic moment values could also be due to the presence of secondary phases in these samples.…

    • 876 Words
    • 4 Pages
    Improved Essays
    Read More

Related Topics

Ready To Get Started?
Discover
Company
Follow
©2024 Cram.com
Privacy Policy |  About Ads |  Site Map |  Advertise  | 
  • Cookie Settings