Essay on Axonal Death And Alzheimer 's Disease

1477 Words Nov 1st, 2016 6 Pages
Introduction Axonal death is a main element in many neurodegenerative diseases. It has been observed in many neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease. Axon degeneration does not necessarily have to involve the typical apoptotic pathway regardless of the morphological similarities to cells undergoing apoptosis. Yang et al. focused on axonal death in traumatic injury because it has been shown to be independent of the necroptotic pathway. This was discovered since treatment with necroptosis inhibitors did not protect axons. To reiterate, axonal death in traumatic injury has commonalities with other diseases such as Alzheimer’s disease and Parkinson’s disease. If there is a greater understanding for the axonal death program underlying these diseases, then therapeutic agents can be made to target certain features of the axonal death program. These researchers focused on the function of the adaptor protein, Sarm1. There was a minor advance that illuminated that axon degeneration decelerates for injured axons when Sarm1 has lost its function. Despite this breakthrough, the other mechanisms in the degeneration of axons involving this adaptor protein are still unknown. Other studies have shown by using a mouse model, deletion of the MAPK kinase kinase (MAPKKK) also delayed the degeneration of injured axons. This led Yang et al. to investigate the MAPK family members. Yang et al. wanted to determine if there was a mitogen-activated protein…

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