Atopic Dermatitis Research Paper

Atopic dermatitis (AD) is a chronic, recurrent and inflammatory disease also known as atopic eczema. Although it most often starts in infancy and affects two of ten children, it is also highly prevalent in adults. Even when this is not a fatal condition, it is characterized by the reduction of the barrier function and shows susceptibility to Staphylococcus aureus. AD is commonly associated with elevated levels of immunoglobulin E (IgE) and T-helper response to allergies. The purpose of this paper is to determine the potential therapeutic benefit microbiome modulation and future the role that microbiota plays in the development of the disease. A total culturable bacteria present on the skin of 17 patients with the diagnosis of AD as compared with 26 healthy volunteers was observed be different suggesting that indeed skin microbiota diversity has an impact in the activation of innate community and the enhanced of Staphylococcus aureus. In this paper it was concluded that gram-negative collection taken from healthy volunteers but not from patients with AD were associated with enhanced barrier function, innate immunity activation, and control of S. aureus. Treatment with CGN from healthy controls improved outcomes in a mouse model of AD The importance of this paper is to determine the future therapeutic benefits to atopic dermatitis. Current therapeutic approaches can significantly improve AD symptoms, yet, even when successful, these treatments are not curative and only control the symptoms.
Outline: …show more content…
• Role of gram genitive and how this affect the barrier factor and innate immune activation
• The role of Staphylococcus aureus in people with atopic dermatitis (AD) and the contribution to AD pathogenesis
• Skin microbiota, how is it different in healthy people and people with atopic