(B) The major appetite signal reception and integration occur in the hypothalamus. In the ARC, the NPY/AgRP neuron (green) produces NPY and AgRP while the POMC/CART neuron (red) produces POMC and CART. These two types of neurons are activated or inhibited by many peripheral signals through cell surface receptors such as Y2R, growth hormone secretagogue receptor (GHSR), leptin receptor (LepR)and insulin receptor( insR.) The signals from these neurons are integrated in PVN and LHA to produce orexigenic or anorexigenic signals through the production of CRH (corticotropin-releasing hormone), TRH (thyrotropin-releasing hormone), ORX (orexin), MCH (melanin-concentrating hormone) etc. Figure adopted from Schellekens et al., (2012).303
(B) The major appetite signal reception and integration occur in the hypothalamus. In the ARC, the NPY/AgRP neuron (green) produces NPY and AgRP while the POMC/CART neuron (red) produces POMC and CART. These two types of neurons are activated or inhibited by many peripheral signals through cell surface receptors such as Y2R, growth hormone secretagogue receptor (GHSR), leptin receptor (LepR)and insulin receptor( insR.) The signals from these neurons are integrated in PVN and LHA to produce orexigenic or anorexigenic signals through the production of CRH (corticotropin-releasing hormone), TRH (thyrotropin-releasing hormone), ORX (orexin), MCH (melanin-concentrating hormone) etc. Figure adopted from Schellekens et al., (2012).303