During the antidepressant treatment phase, we found 1) the OSA group performed significantly worse on the SRT delayed recall at week 16 compared to the non-OSA group, and the results remained significant after controlling for baseline performance, age, gender, and education; 2) the OSA group had a greater microvascular burden, including DWMHs, PVHs, and SCGs, as well as grade 2 and 3 lesions in DWM, PVH, and SCG, 3) between groups, the differences in the hippocampal and entorhinal cortex volumes were not statistically different, and the results do not change after controlling for intracranial volume.
In ANCOVA analysis, the OSA group performed significantly worse than the non-OSA group on the SRT-delayed recall (p=0.000) only after antidepressant…