Depression is a brain disorder which generate major disability. Its etiology and molecular mechanism is not fully understood. It is a leading cause of disability globally, with lifetime prevalence as high as 20% (Kessler et al., 2005). Depression is multifactorial disorders that differ in symptomology and most possibly in etiology. There are various symptoms of depression include depressed mood, mood swing, loss of pleasure activities (anhedonia), inability to concentrate, lack of energy, disturbed sleep or appetite, feelings of worthlessness or guilt, and suicidal ideation and tendencies etc.(DSM-IV)(1994).
Animal models of depression have a function of to replicate some known aspects of depression in preferred animal species (e.g. rodents). …show more content…
Beside this, there is no discovery of highly penetrant genetic variants that cause depression. Therefore, depression is diagnosed by increased activity of the hypothalamic pituitary axis HPA-axis that controls stress responses. In human depression such anomalies are not observed, nor are they strong sufficiently to be usefully oppressed both in constructing and testing animal models. Animal models offer a strong methodology for examining the disease problems and enlarge some therapies. Homologous models are very uncommon in the field of neuroscience. There are some isomorphic models which are more universal, but they show analogous symptoms. Animal models have got two main uses in the field of neuroscience research, first is the development and testing of theory about neurological and psychiatric disorders and second is the improvement of drugs and relevant therapies (De Dyne et al 2000, Geyer and Markou, 2002 Mitchell and redfern 2005; Wong 2005) demonstrated that these two currently available models do not meet these two requirements. Animal models provide explanations for two main symptoms of depression, one is depressed and other is loss of attention or pleasure which is also …show more content…
A model which parallels numerous symptoms of human depression is considered important. It is well known that animal models should share phenomenological similarities isomorphism with the human pathology to be modeled. In other words we can say that it is phenomenological similarities between the behavior shown by the animal model and the particulars symptoms of the human condition (Geyer and Markou 1995; Moreau 2002; Lyon 2004) .The face validity of animal model of depression is a determination of the models capability to replicate core symptoms of the disease (Mitchell and Redfern, 2005).
In using the face validity of animal models of depression, anhedonia as a result assumes an important position. Anhedonia is also a most important symptom of psychosis. In case of animal models drug promote reversal of anhedonia, while greatly encouraging, should be considered in relation to DSM-IV criteria for both depressive illness and
Animal models of depression have a function of to replicate some known aspects of depression in preferred animal species (e.g. rodents). …show more content…
Beside this, there is no discovery of highly penetrant genetic variants that cause depression. Therefore, depression is diagnosed by increased activity of the hypothalamic pituitary axis HPA-axis that controls stress responses. In human depression such anomalies are not observed, nor are they strong sufficiently to be usefully oppressed both in constructing and testing animal models. Animal models offer a strong methodology for examining the disease problems and enlarge some therapies. Homologous models are very uncommon in the field of neuroscience. There are some isomorphic models which are more universal, but they show analogous symptoms. Animal models have got two main uses in the field of neuroscience research, first is the development and testing of theory about neurological and psychiatric disorders and second is the improvement of drugs and relevant therapies (De Dyne et al 2000, Geyer and Markou, 2002 Mitchell and redfern 2005; Wong 2005) demonstrated that these two currently available models do not meet these two requirements. Animal models provide explanations for two main symptoms of depression, one is depressed and other is loss of attention or pleasure which is also …show more content…
A model which parallels numerous symptoms of human depression is considered important. It is well known that animal models should share phenomenological similarities isomorphism with the human pathology to be modeled. In other words we can say that it is phenomenological similarities between the behavior shown by the animal model and the particulars symptoms of the human condition (Geyer and Markou 1995; Moreau 2002; Lyon 2004) .The face validity of animal model of depression is a determination of the models capability to replicate core symptoms of the disease (Mitchell and Redfern, 2005).
In using the face validity of animal models of depression, anhedonia as a result assumes an important position. Anhedonia is also a most important symptom of psychosis. In case of animal models drug promote reversal of anhedonia, while greatly encouraging, should be considered in relation to DSM-IV criteria for both depressive illness and