“Animals that develop toxic injury or disease during toxicology research and testing studies often experience significant pain, distress, suffering, and/or death. Nearly all of the estimated 2000 new chemicals and thousands of chemical products introduced each year must undergo acute safety tests to determine whether the substance is toxic or lethal and whether it causes allergic skin reactions or damage to eyes or skin. Much of this acute testing is still conducted using mice, rats, guinea pigs, and rabbits, with many animals experiencing death, acute illness, pain, and distress from toxic effects. Many substances also require chronic toxicity and carcinogenicity studies that use over 600 rats and mice dosed for 2 year, during which up to 50% of the animals die or must be euthanized before the end of the study because of severe chronic disease and/or excessive tumor burden” (stokes,
“Animals that develop toxic injury or disease during toxicology research and testing studies often experience significant pain, distress, suffering, and/or death. Nearly all of the estimated 2000 new chemicals and thousands of chemical products introduced each year must undergo acute safety tests to determine whether the substance is toxic or lethal and whether it causes allergic skin reactions or damage to eyes or skin. Much of this acute testing is still conducted using mice, rats, guinea pigs, and rabbits, with many animals experiencing death, acute illness, pain, and distress from toxic effects. Many substances also require chronic toxicity and carcinogenicity studies that use over 600 rats and mice dosed for 2 year, during which up to 50% of the animals die or must be euthanized before the end of the study because of severe chronic disease and/or excessive tumor burden” (stokes,