Animal Model For HCM

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Another important animal model for HCM is the zebrafish. The fish model is a powerful tool to study several cardiovascular diseases and is particularly important in heart development, due to some key characteristics such as the external development of the heart, allowing non-invasive analysis of the heart during its formation. Also, zebrafish embryos initially do not rely on the cardiovascular system for oxygen, and those with HCM-associated gene modifications can survive and continue development for several days. Finally, although the zebrafish heart is simpler in structure than mammals, the essential genes responsible for heart development are conserved.[110, 111] One group developed a TNNT2 human mutation model in zebrafish to assess its

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