Analysis Of Gemifloxacin Mesylate

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ANALYTICAL METHODS
Determination of λ max
Gemifloxacin mesylate λ max is determined by preparing one standard concentration of 10μg/ml and scanning should be done. Preparation of 0.1N HCL
8 ml of hydrochloric acid is taken in 1000ml volumetric flask and dissolved with distilled water and then make up to 1000ml with distilled water. Standard graph of Gemifloxacin mesylate:
The λmax of Gemifloxacin mesylate in 0.1N HCL was scanned in UV-Visible Spectrophotometer and found to have maximum absorbance at 271nm.100mg of Gemifloxacin was weighed and transferred into 100ml volumetric flask. To this, small quantity of 0.1N HCL is added to dissolve the drug. Then the solution was made up to 100ml using 0.1N HCL. This is stock solution-A. (1mg/ml).
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DRUG PROPERTIES:
The following properties of the active ingredient specified are evaluated during preformulation study.
a) Angle of Repose
The fixed funnel method was employed to measure the angle of repose. A funnel was secured with its tip at a given height ‘h’ above a graph paper that was placed on a flat horizontal surface. The blend was carefully pored through the funnel until the apex of the conical pile just touched the tip of the funnel. The radius, r of the base of the conical pile was measured. The angle of repose, α, was calculated using the following formula: (Copper J, et al., 1986). Α = tan-1 h/r
b) Bulk Density
30gms of material was passed through a sieve no. 25 to break up agglomerates and introduced into a dry 100ml cylinder. Without compacting, the powder was carefully leveled and the unsettled apparent volume, Vo, was read. The bulk density was calculated, in grams per ml, using the formula (Shah et al., 1997).
Bulk density = (M) / (VO)
Where, M = Total mass of the
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Hausner ratio = Vo/ Vf Vo = Bulk volume, Vr= Tapped volume
EVALUATION PARAMETERS OF FLOATING TABLETS
1) Test for Weight variation:
Twenty (20) tablets from each batch were individually weighed in grams on an analytical balance. The average weight and standard deviation were calculated, individual weight of each tablet was also calculated using the same and compared with average weight56.
Weight Variation limits as per USP Average weight in mg % ± deviation allowed 130 or Less 10 130-223 7.5 More than 324 5

2) Test for Thickness:
The thickness in millimeters (mm) was measured individually for 10 pre weighed tablets by using a Vernier Caliperse. The average thickness and standard deviation were

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