Alzheimer disease (AD) is a neurodegenerative disease that causes severe memory impairment due to the destruction of neurons in the hippocampus and entorhinal cortex (NIH 2016a). There are two classifications of Alzheimer 's disease; early-onset and late-onset. Early-onset Alzheimer refers to individuals who are between the ages of 30 to 60 while late-onset Alzheimer refers to individuals who are above 60 years of age (NIH 2016b).
Individuals who possess the apolipoprotein E gene or are over 65 years of age have an elevated probability of developing the disease, which increases as they age (NIH 2016c). Furthermore, there is a significant correlation between the APOE4 allele and AD due to the fact that participants in the Canadian Study …show more content…
Genetic mutation is commonly the determinant that causes AD in individuals under 65 while individuals over 65 are predominantly developing Alzheimer 's due to modifications in the brain over several decades (NIH 2016b). In addition, AD causes degeneration of the brain and memory loss due to substantially less synapses and neurons (AA 2016b, Brightfocus Foundation 2016). Neurofibrillary tangles consisting of twisted tau proteins inhibit the brain from receiving nutrients via the microtubule and plaque made of beta-amyloid bundled together blocks communication between neurons (AA 2016b). Individuals who are over 65 years old or have health concerns related the circulatory system have an accelerated deterioration rate (AS 2016). In the early stages of AD, there is a small variation in behaviour and lack of memory, but as the disease progresses over time, their cognitive abilities will worsen (AS 2016). Early stages of AD consist of lack of memory and inconsequential variation in behaviour or abilities (AS 2016). Middle stages of Alzheimer 's involve memory loss or experience delusion and will require assistance with daily activities (AS 2016). Late stages of Alzheimer progressively worsen and will become completely reliant on the nursing care of others due to difficulty eating, incontinence, walking and loss of speech the individual experiences (AS
Individuals who possess the apolipoprotein E gene or are over 65 years of age have an elevated probability of developing the disease, which increases as they age (NIH 2016c). Furthermore, there is a significant correlation between the APOE4 allele and AD due to the fact that participants in the Canadian Study …show more content…
Genetic mutation is commonly the determinant that causes AD in individuals under 65 while individuals over 65 are predominantly developing Alzheimer 's due to modifications in the brain over several decades (NIH 2016b). In addition, AD causes degeneration of the brain and memory loss due to substantially less synapses and neurons (AA 2016b, Brightfocus Foundation 2016). Neurofibrillary tangles consisting of twisted tau proteins inhibit the brain from receiving nutrients via the microtubule and plaque made of beta-amyloid bundled together blocks communication between neurons (AA 2016b). Individuals who are over 65 years old or have health concerns related the circulatory system have an accelerated deterioration rate (AS 2016). In the early stages of AD, there is a small variation in behaviour and lack of memory, but as the disease progresses over time, their cognitive abilities will worsen (AS 2016). Early stages of AD consist of lack of memory and inconsequential variation in behaviour or abilities (AS 2016). Middle stages of Alzheimer 's involve memory loss or experience delusion and will require assistance with daily activities (AS 2016). Late stages of Alzheimer progressively worsen and will become completely reliant on the nursing care of others due to difficulty eating, incontinence, walking and loss of speech the individual experiences (AS