Summary:
Neurodegeneration is a collective term characterized by structural and functional loss of neurons which is a gradual and progressive process. Various neurodegenerative diseases like Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, etc. have been described by many biomarkers that are unusual in comparison to their baseline levels in the brain regions. Out of all the diseases, Alzheimer’s disease is the most prevailing disease in older patients with an average age greater than 65 years. Alzheimer’s disease (AD) is illustrated by irreversible neuron loss causing cognitive dysfunction and memory loss. AD affects 30 million people worldwide and is thought to affect 60 million people till 2050[1]. All the treatments for AD …show more content…
The methoxy groups and the ketone group give the molecule a surface anionic charge which helps in binding to the target site. Indanone ring provides metabolic stability to the compound and so donepezil has a longer half-life.
Physical properties:
Donepezil is mainly given in its hydrochloride form. It is a white crystalline powder and is freely soluble in chloroform and soluble in …show more content…
Donepezil has a substantial effect on levels of AChE in brain in comparison with the levels in other smooth, skeletal and cardiac muscles. Its effect on AChE levels in synapses closely resembles to that in RBC and as a result its effect on RBC gives an idea about the efficiency of donepezil. Donepezil is a weak inhibitor of butyrylcholinesterase (pseudocholinesterase), an enzyme abundantly present in the periphery and plasma and so it eliminates the occurrence of side-events due to its action on
Neurodegeneration is a collective term characterized by structural and functional loss of neurons which is a gradual and progressive process. Various neurodegenerative diseases like Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, etc. have been described by many biomarkers that are unusual in comparison to their baseline levels in the brain regions. Out of all the diseases, Alzheimer’s disease is the most prevailing disease in older patients with an average age greater than 65 years. Alzheimer’s disease (AD) is illustrated by irreversible neuron loss causing cognitive dysfunction and memory loss. AD affects 30 million people worldwide and is thought to affect 60 million people till 2050[1]. All the treatments for AD …show more content…
The methoxy groups and the ketone group give the molecule a surface anionic charge which helps in binding to the target site. Indanone ring provides metabolic stability to the compound and so donepezil has a longer half-life.
Physical properties:
Donepezil is mainly given in its hydrochloride form. It is a white crystalline powder and is freely soluble in chloroform and soluble in …show more content…
Donepezil has a substantial effect on levels of AChE in brain in comparison with the levels in other smooth, skeletal and cardiac muscles. Its effect on AChE levels in synapses closely resembles to that in RBC and as a result its effect on RBC gives an idea about the efficiency of donepezil. Donepezil is a weak inhibitor of butyrylcholinesterase (pseudocholinesterase), an enzyme abundantly present in the periphery and plasma and so it eliminates the occurrence of side-events due to its action on