Definition As per NINCDSADRDA criteria Alzheimer’s disease is defined as a “clinical disease caused by underlying brain changes”. Dementia is the characteristic clinical manifestation of disease. The definition of AD revolves around the assumption that an individual with an amnestic dementia would have Alzheimer’s related brain changes, namely amyloid plaques and tau neurofibrillary tangles, found at autopsy. Conversely, individuals without amnestic dementia would not found plaques or tangles at autopsy. This definition of Alzheimer’s intertwines the signs and symptoms of dementia and the underlying brain changes.
Epidemiology
With the increasing life expectancy and availability of better healthcare systems, the population of elderly is increasing
Epidemiology
With the increasing life expectancy and availability of better healthcare systems, the population of elderly is increasing