Athletic performance has a significant association with ACTN-3 genotype. It produces the protein α-actinin-3 that is found in in fast-twitch muscle fibres which are responsible for generating force for high-velocity movement. Yang et al. hypothesize that α-actinin-3 can influence sprint and power activities by “promoting fast-twitch muscle fiber formation or changing the glucose metabolism during athletic training.” α-actinin-3 may promote the “absorption or transmission of force during muscle contraction,” resulting in less damage.
Their research has shown that the R and X allele of ACTN-3 have an impact in athleticism. According to their research, the XX genotype is more frequent in endurance athletes while the RR genotype is more frequent in power athletes. The R allele produces a lot of the α-actinin-3 protein and the X allele puts a premature stop to the growing protein chain resulting in a non-functional α-actinin-3 protein. α-actinin-3 is not necessary in normal muscle function, but it is associated with muscle strength. The X allele, on the other hand, can give an advantage on slow, efficient muscle performance, which may make it enhance endurance performance. The data from their study showed that more endurance athletes have the XX genotype is more endurance athletes have the XX genotype, indicating that the X allele may have an enhancing effect on endurance. …show more content…
The XX genotype is more frequent in endurance athletes than power athletes and controls. The RR genotype is most frequent in power athletes compared to endurance athletes and