Agmatine is a well known neurotransmitter. It also works as a neuromodulator in certain processes in the body. It is prepared through the removal of a carboxylic group from L-Arginine. It is naturally stored in the neurons and therefore used in the nervous system whenever required.
Agmatine was discovered over 100 years ago in 1910 by Kossel. Its mechanisms of actions on different body functions though have just been discovered. Current research shows that agmatine has the potential for use in order to treat drug addiction and reduced neuropathic pain. It can also protect the brain from the effect of toxins.
The direct use of agmatine is not suitable for pain relief as it can elevate pain in people. The drug has an excellent synergy with most …show more content…
This means that agmatine removes quickly from tissues that have high DAO levels such as in the kidney, epithelial tissues and smooth muscle cells. They remain for a long period in the brain, liver and skeletal tissues due to the naturally lower levels of DAO.
10% of the agmatine can also convert into polyamines such as putrescine through different mechanisms. One mechanism produces urea as a byproduct while the other produces ammonia during the indirect conversion.
Agmatine as a Supplement?
The current research on animals suggests that agmatine has a wide potential for use as a supplement. It cannot be used right now due to the lack of studies done on the humans. Some studies have now appeared but all of these employ the use of agmatine injections. It needs to be thoroughly tested for ingestion first before being termed suitable for supplement use.
There has not been much testing on humans therefore it not possible to discuss the toxic nature of agmatine in the finer detail. It is best to remain with the current dose of 2670 mg which was used in human
Agmatine was discovered over 100 years ago in 1910 by Kossel. Its mechanisms of actions on different body functions though have just been discovered. Current research shows that agmatine has the potential for use in order to treat drug addiction and reduced neuropathic pain. It can also protect the brain from the effect of toxins.
The direct use of agmatine is not suitable for pain relief as it can elevate pain in people. The drug has an excellent synergy with most …show more content…
This means that agmatine removes quickly from tissues that have high DAO levels such as in the kidney, epithelial tissues and smooth muscle cells. They remain for a long period in the brain, liver and skeletal tissues due to the naturally lower levels of DAO.
10% of the agmatine can also convert into polyamines such as putrescine through different mechanisms. One mechanism produces urea as a byproduct while the other produces ammonia during the indirect conversion.
Agmatine as a Supplement?
The current research on animals suggests that agmatine has a wide potential for use as a supplement. It cannot be used right now due to the lack of studies done on the humans. Some studies have now appeared but all of these employ the use of agmatine injections. It needs to be thoroughly tested for ingestion first before being termed suitable for supplement use.
There has not been much testing on humans therefore it not possible to discuss the toxic nature of agmatine in the finer detail. It is best to remain with the current dose of 2670 mg which was used in human