Aging Of Aging And Aging Associated With Learning And Memory Storage

901 Words Feb 16th, 2016 4 Pages
Despite the advances in the physiological and molecular understanding of aging1-4, the aging-dependent alterations in specific neurons that are critical for learning and memory storage are poorly understood. Such information is essential to delineate the molecular underpinnings of aging-related changes to develop novel strategies for therapeutic intervention of the aging-associated deficits in learning and memory storage. Our proposed studies are highly significant to aging associated memory loss in three major ways. (1) This proposal is highly relevant to human learning because of the focus on mechanisms of aging dependent changes in learning using a simple, but well characterized neural circuitry - the gill withdrawal reflex (GWR) of Aplysia. It is important to recognize that many concepts that are central to our overall understanding of learning and memory were established using Aplysia. For instance, the role of the cAMP signaling system, or branch-specific storage of memories discovered in Aplysia has also been shown to be important in Drosophila and the mouse5. Therefore, it is expected that contributions of the proposed studies on aging will be conserved in mammals. (2) Studying aging using defined synapses is critical for identifying specific cellular and molecular mechanisms of aging associated memory decline for two main reasons. First, studies using populations of neurons will dilute the specific changes caused by aging at the cellular level. For example, our…

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