Addison's Disease

Addison's disease and Cushing's syndrome

Addison Disease, arises when there is hyposecretion of adrenocortical hormones, resulting in decreases cortisol and aldosterone levels while Crushing syndrome is when there is hypersecretion of adrenocortical hormones, leading to increased secretion. According to Hunt, other causes for Addison’s disease is commonly caused by an autoimmune response to an infection or cancer, while crushing “can result from long-term use of high-dose glucocorticoid therapy” or other underlying causes like a pituitary tumor(Hunt 2012).

In Addison Disease, the lack of cortisol, aldosterone, and other adrenal hormones, causes patients to have personality changes, hyperpigmentation, hypotension,diarrhea, pain, muscle weakness,