AD57 (hydrochloride)
Description:
IC50: 2 nM: blocks the receptor tyrosine kinase RET in Drosophila.
AD57, as a polypharmacological cancer therapeutic, is designed to regulate multiple targets related to cancer. AD57 effectively suppresses tyrosine kinase RET, weakens the activity of numerous other kinases, and interferes with kinases downstream of RET, including Raf, Src, and S6K, providing further efficacy in preventing signaling leading to invasion, proliferation, and metabolism related to cancer. Tyrosine kinase RET is probably sufficient to trigger a series of transformation events including medullary thyroid carcinoma (MTC), multiple endocrine neoplasias type 2A (MEN2A) and 2B (MEN2B).
In vitro: AD57 was demonstrated to inhibit
Description:
IC50: 2 nM: blocks the receptor tyrosine kinase RET in Drosophila.
AD57, as a polypharmacological cancer therapeutic, is designed to regulate multiple targets related to cancer. AD57 effectively suppresses tyrosine kinase RET, weakens the activity of numerous other kinases, and interferes with kinases downstream of RET, including Raf, Src, and S6K, providing further efficacy in preventing signaling leading to invasion, proliferation, and metabolism related to cancer. Tyrosine kinase RET is probably sufficient to trigger a series of transformation events including medullary thyroid carcinoma (MTC), multiple endocrine neoplasias type 2A (MEN2A) and 2B (MEN2B).
In vitro: AD57 was demonstrated to inhibit