Acyclovir Synthesis

the elongation step of viral DNA replication. The study showed that Acyclovir is phosphorylated into monophosphate purine analog, and remained in the infected cells before being converted into the triphosphate active form by the viral thymidine kinase. Once in this form, DNA polymerase will substitute it for Guanine triphosphate into the viral DNA chain. Due to Acyclovir’s structure, the lack of a second hydroxyl group prevents another residue to be attached and terminates chain growth. This mode of action for chain termination became a standard in drug development as more compounds that acted as nucleoside analogs were developed (1).
The next drug developed that became the standard for HSV treatments was Penciclovir. This drug is also effective