Migraine causes are still not understood but genetics and environmental factors appear to play an important role in this diseases. Migraines may be caused by changes in the brainstem and its interactions with the trigeminal nerve, a major pain pathway.
Pain in the nervous system also may occur when there are imbalances in brain chemicals including serotonin. Role of serotonin in migraines are still studying by the researchers. During migraine attacks, serotonin levels may drop. Substances called neuropeptides may release by trigeminal nerve which will move to the brain’s outer covering ( meninges ). Other neurotransmitters play a role in the pain of migraine, including calcitonin gene-related peptide (CGRP) ( Swanson, 2016 ).
Pain in the nervous system also may occur when there are imbalances in brain chemicals including serotonin. Role of serotonin in migraines are still studying by the researchers. During migraine attacks, serotonin levels may drop. Substances called neuropeptides may release by trigeminal nerve which will move to the brain’s outer covering ( meninges ). Other neurotransmitters play a role in the pain of migraine, including calcitonin gene-related peptide (CGRP) ( Swanson, 2016 ).