Any agent that interferes with enzyme activity is an inhibitor. Inhibitors can affect the catalysis and/or the binding of enzymes to substrate. (McMichael) Malonate is an inhibitor of SDH mainly because of its shape and function. The shape is similar to that of succinate. (Clark, 2009) Malonate would bind at the same active site, competing with SDH, therefore inhibiting a reaction. The enzyme cannot act further once bound with malonate. (4) Malonate is labeled as a competitive inhibitor since it competes for the site with SDH. (Clark, 2009)
Malonate is a major inhibitor of Succinate Dehydrogenase to the point where if malonate is added to an active respiring mitochondria the oxygen consumption stops and a metabolic intermediate starts. [2]
Malonate is a major inhibitor of Succinate Dehydrogenase to the point where if malonate is added to an active respiring mitochondria the oxygen consumption stops and a metabolic intermediate starts. [2]