A Study On Loss Of Cell Adhesion Essay examples

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CDH2 gene codes for the protein N-cadherin, also known as Cadherin-2 (CDH2), or neural cadherin (NCAD). Studies on this gene has discovered that it is located on Chromosome 18-NC_000018.10, assembly GRCh38.p2 on humans, and contains 20 exons.(9) N-cadherin is one of the classification of the cadherin superfamily, and is composed of five extracellular cadherin repeats, highly conserved cytoplasmic tail and a transmembrane region. This protein’s purpose is to mediate cell-cell adhesion by interacting with adjacent cell in an anti-parallel conformation, forming a linear zip-like adhesion between cells.(9) The adhesion is calcium dependent.(10) N-cadherin have roles in development, neural tissues, cardiac muscles and in cancer metastasis. This does this via cadherin switching, which is a process where there are switches in E-cadherin expression and expression of N-cadherin, as they are complimentary to each other.(10)

Loss of cell-cell adhesion is one of the first steps of cancer metastasis, invasion, and progression, which is as a result of activation of EMT. N-cadherin is a mesenchymal stem cell marker and as more of these are expressed, E-cadherin and P-cadherin decreases, which are epithelial cell markers.(10) The cell is then considered to be a cancer cell. These markers are located on the cell surfaces, and are used to identify different types of cells, and give specific characteristics of the cell.(11) With the rise of N-cadherin and loss of E-cadherin expression…

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