A Study On Drug Therapy Regimen Variance Essay

1652 Words Oct 26th, 2016 7 Pages
Aptiom and Phenytoin may both be anticonvulsants, yet they have many points of contrasting variation which exemplify their individual advantages and disadvantages. For example, they have differing amounts of clinical research, drug therapy regimen variance, and cost differences that make the each drug distinct and highly distinguishable from the other. Phenytoin was first synthesized in 1908 and was approved by the FDA in 1939 (Ogbru, n.d). Since then, it has become one of the most commonly used antiepileptic medications in North America. An extensive amount of careful scientific trials has been done in a great number of patients (Epilepsy Foundation, n.d). It is best used to treat partial-onset seizures, but has value in treating tonic-clonic seizures, myoclonic seizures, atonic seizures, and seizures which occur during or after neurosurgery (Ogbru, n.d, Epilepsy Foundation, n.d). Its exact action is unknown, but it is thought to reduce the sensitivity and transmission of brain nerves, slowing the impulses in the brain that cause seizures. Extensive research suggests that this reduction is caused by blocking voltage dependent neuronal sodium channels, therefore limiting action potentials from firing. Aptiom is a new anticonvulsant drug only approved by the FDA on November 8th, 2013. Similarly, to phenytoin, its exact mechanism of action is unknown, but it may block voltage gated sodium channels. This blocking reduces the ability of neurons to send signals, therefore…

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