A Short Note On Mellitus And Type II Non Insulin Dependent Diabetes Mellitus

1040 Words Aug 24th, 2015 5 Pages
Pathophysiology of Type I IDDM and Type II NIDDM
Type I Insulin dependent Diabetes Mellitus (IDDM) and Type II Non-Insulin dependent Diabetes Mellitus (NIDDM) are two separate pathophysiological features that separate them from one another.
Type I Insulin dependent Diabetes Mellitus (IDDM) "results from immune-mediated destruction of the insulin-producing beta cells of the pancreas" (Kantárová, 2007, p. 1). Individuals that are genetically susceptible to IDDM produce autoantibodies that becomes triggered after a viral infection affects the body. The autoantibodies targets and destroys the pancreas ' insulin-producing beta cells which results in a decline in secretion of insulin and insulin deficiency.
Type II Non-insulin dependent Diabetes Mellitus (NIDDM) “results from an imbalance between insulin sensitivity and insulin secretion” (DeFronzo, 1992, p 1). NIDDM is a chronic disease caused by one or more factors such as: inappropriate hepatic glucose production, peripheral insulin receptor insensitivity, and/or impaired insulin production from the pancreas. Insulin resistance from the peripheral receptors cause an increase production in insulin from beta cells where over several years the beta cells become fatigued then the lack of insulin produce from the beta cells in the pancreas results in increase glucose production from the liver resulting in hyperglycemia and ultimately NIDDM.
Signs and Symptoms of IDDM and NIDDM
Signs and symptoms for Type I Insulin dependent…

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