We now know that gout also can be caused by certain medications that raise uric acid levels, such as aspirin; diuretics, such as hydrochlorothiazide; and immunosuppressant drugs, such as cyclosporine (rheumatology.org ).
Chronic gout can lead to crystal deposits (sodium orate) of uric acid (a normal byproduct of purines) in the tissues, particularly in and around the joints. Either the body starts to increase production of uric acid or, more often, the kidneys cannot remove the uric acid well enough, so it builds up. Some of the needle-shaped crystals move outside the bloodstream and usually take hold around the joints. This causes severe pain and inflammation and over a longer period of time, can cause joint destruction.…