Carvacrol modulates instability of xenobiotic metabolizing enzymes and downregulates the expressions of PCNA, MMP-2, and MMP-9 during diethylnitrosamine-induced hepatocarcinogenesis in rats
Covered By: Kiauna Pinnock & Weschester Junior Nine researchers in the fields of biochemistry, nanoscience & technology and medical biotechnology from various research institutes and universities came together with an interest in Hepatocellular Carcinoma (HCC). HCC is one type of the malignant tumors that occur in the liver. It is the fifth most common worldwide and third most common cause of cancer mortality. With that in mind, these nine researcher did some foot work and came across Diethylnitrosamine or DEN, which is one of the most important environmental …show more content…
As DEN exposure leads to the formation of major pro-mutagenic ethyl adducts, which can further lead to cancer in the liver. Now armed with a way to cause liver cancer, the researchers searched for ways to prevent or reverse it. Using the present efforts of other researchers toward natural remedies they came across Carvacrol. Generally recognized as a safe food additive, carvacrol is a natural isopropyl cresol present in the essential oil of oregano, thyme, pepperwort and wild bergamot. As it has been shown that antioxidants have potent antiplatelet, anti-proliferative and anti-carcinogenic effects, the researchers were pleased with their findings of carvacrol’s anti-proliferative effect in other studies. What
Covered By: Kiauna Pinnock & Weschester Junior Nine researchers in the fields of biochemistry, nanoscience & technology and medical biotechnology from various research institutes and universities came together with an interest in Hepatocellular Carcinoma (HCC). HCC is one type of the malignant tumors that occur in the liver. It is the fifth most common worldwide and third most common cause of cancer mortality. With that in mind, these nine researcher did some foot work and came across Diethylnitrosamine or DEN, which is one of the most important environmental …show more content…
As DEN exposure leads to the formation of major pro-mutagenic ethyl adducts, which can further lead to cancer in the liver. Now armed with a way to cause liver cancer, the researchers searched for ways to prevent or reverse it. Using the present efforts of other researchers toward natural remedies they came across Carvacrol. Generally recognized as a safe food additive, carvacrol is a natural isopropyl cresol present in the essential oil of oregano, thyme, pepperwort and wild bergamot. As it has been shown that antioxidants have potent antiplatelet, anti-proliferative and anti-carcinogenic effects, the researchers were pleased with their findings of carvacrol’s anti-proliferative effect in other studies. What